C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers.

@article{Wang2000CCAM1AC,
  title={C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers.},
  author={Lei E. Wang and Scott Lin and Wei Wu and Bonnie L. Kemp and Garrett Lyndon Walsh and Waun Ki Hong and Li Mao},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2000},
  volume={6 8},
  pages={
          2988-93
        }
}
Previous studies have shown that the expression of the cell-cell adhesion molecule (C-CAM1), located at chromosome 19, is down-regulated in several types of human cancers, including prostate and breast cancers. Two major isoforms of C-CAM1, the long or L-form C-CAM1 and the short or S-form C-CAM1, are derived from the C-CAM1 gene through alternative splicing. Tumor cells transfected with L-form C-CAM1, which contains a cytoplasmic domain, display significantly lower growth rates and less… CONTINUE READING
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