C-C chemokine receptor 5 gene variants in relation to lung disease in sarcoidosis.

@article{Spagnolo2005CCCR,
  title={C-C chemokine receptor 5 gene variants in relation to lung disease in sarcoidosis.},
  author={Paolo Spagnolo and Elisabetta A Renzoni and Athol U Wells and Susan Jennifer Copley and Sujal R. Desai and Hiroe Sato and Jan C. Grutters and Atiyeh Abdallah and Anne Barbara Taegtmeyer and Roland M du Bois and Kenneth I. Welsh},
  journal={American journal of respiratory and critical care medicine},
  year={2005},
  volume={172 6},
  pages={
          721-8
        }
}
RATIONALE Genetic factors are likely to influence the clinical course and pattern of sarcoidosis, a granulomatous disease of unknown origin. OBJECTIVES We tested this hypothesis for C-C chemokine receptor 5 (CCR5), a molecule involved in recruitment and activation of mononuclear cells. METHODS In addition to the known CCR5 Delta 32 insertion/deletion, we evaluated a further eight single-nucleotide polymorphisms in 106 British patients and 142 British unaffected subjects, and second-setted… CONTINUE READING

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C–C chemokine receptor 5 and sarcoidosis: association with radiological stages of disease

  • P Spagnolo, EA Renzoni, +7 authors RM du Bois
  • Am J Respir Crit Care Med ;169:A218
  • 2004
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