C-7 configuration as one of determinants in taxanes metabolism by human cytochrome P450 enzymes.


Taxanes exhibit a high tendency to epimerize at C-7 under physiological conditions. This study aimed to investigate the composite effect of C-7 configuration and other substructural elements on the metabolic properties of taxanes. Cephalomannine, 7-epi-cephalomannine, 10-deacetyl-paclitaxel, and 7-epi-10-deacetyl-paclitaxel were chosen as model compounds… (More)
DOI: 10.3109/00498250903271989


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