C-6 glioma growth in rats: suppression with a beta-adrenergic agonist and a phosphodiesterase inhibitor.

@article{ChelmickaSchorr1980C6GG,
  title={C-6 glioma growth in rats: suppression with a beta-adrenergic agonist and a phosphodiesterase inhibitor.},
  author={Ewa Chelmicka-Schorr and Barry G. W. Arnason and Scott Holshouser},
  journal={Annals of neurology},
  year={1980},
  volume={8 4},
  pages={
          447-9
        }
}
Rat C-6 glioma possesses a beta-adrenergic receptor which, when activated, raises intracellular levels of cyclic adenosine monophosphate (cAMP) in cultured C-6 glioma cells. The present study shows that growth of C-6 glioma is suppressed in rats treated with the beta-adrenergic agonist isoproterenol. Addition of papaverine, a cAMP phosphodiesterase inhibitor, to the treatment schedule augments this effect. Pharmacological agents that elevate intracellular cAMP levels may retard the growth of… CONTINUE READING
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