C-5 Substituted heteroaryl 3-pyridinecarbonitriles as PKCtheta inhibitors: Part I.

Abstract

We earlier reported that 3-pyridinecarbonitriiles with a 4-methylindolyl-5-amino group at C-4 and a phenyl group at C-5 were inhibitors of PKCtheta. Keeping the group at C-4 of the pyridine core constant, we varied the water solubilizing group on the phenyl ring at C-5 and then replaced the C-5 phenyl ring with several monocyclic heteroaryl rings, including… (More)
DOI: 10.1016/j.bmcl.2009.07.109

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Cite this paper

@article{Subrath2009C5SH, title={C-5 Substituted heteroaryl 3-pyridinecarbonitriles as PKCtheta inhibitors: Part I.}, author={Joan J. Subrath and Daniel Y.C. Wang and Biqi Wu and Chuansheng Niu and Diane H Boschelli and Julie M. Lee and Xiaoke Yang and Agnes M. Brennan and Divya Chaudhary}, journal={Bioorganic & medicinal chemistry letters}, year={2009}, volume={19 18}, pages={5423-5} }