C-3 epimers can account for a significant proportion of total circulating 25-hydroxyvitamin D in infants, complicating accurate measurement and interpretation of vitamin D status.

Abstract

CONTEXT We have recently introduced liquid chromatography-tandem mass spectrometry (LC-MS/MS) for 25-hydroxyvitamin D(2) (25OHD(2)) and 25OHD(3) testing. During subsequent clinical use, we identified significantly elevated results in some infants. We hypothesized this might represent assay interference caused by C-3 epimers of 25OHD(2) or 25OHD(3… (More)

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@article{Singh2006C3EC, title={C-3 epimers can account for a significant proportion of total circulating 25-hydroxyvitamin D in infants, complicating accurate measurement and interpretation of vitamin D status.}, author={Ravinder Jit Singh and Robert Lee Taylor and G. Satyanarayana Reddy and S. Grebe}, journal={The Journal of clinical endocrinology and metabolism}, year={2006}, volume={91 8}, pages={3055-61} }