C-17 lactam-bearing limonoids from the twigs and leaves of Amoora tsangii.

  title={C-17 lactam-bearing limonoids from the twigs and leaves of Amoora tsangii.},
  author={Guo-Yuan Zhu and G. Chen and Liang Liu and L. Bai and Zhihong Jiang},
  journal={Journal of natural products},
  volume={77 4},
  • Guo-Yuan Zhu, G. Chen, +2 authors Zhihong Jiang
  • Published 2014
  • Chemistry, Medicine
  • Journal of natural products
  • Twelve new lactam-bearing limonoids, amooramides A-L (1-12), were isolated from the twigs and leaves of Amoora tsangii, and their structures fully elucidated by spectroscopic analysis. These compounds represent the first examples of rings A,B-seco-limonoids bearing unusual lactam side chains at C-17, including a 3-substituted 1,5-dihydro-2H-pyrrol-2-one moiety in 1-7 and a 4-substituted 1,5-dihydro-2H-pyrrol-2-one unit in 8-12. Compound 9 inhibited TNFα-induced NF-κB activity by 64% at a… CONTINUE READING
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