C(5)-C(5a)-modified bicyclomycins: synthesis, structure, and biochemical and biological properties.

@article{Vincent2001C5C5amodifiedBS,
  title={C(5)-C(5a)-modified bicyclomycins: synthesis, structure, and biochemical and biological properties.},
  author={F Vincent and J Srinivasan and Alejandro Santill{\'a}n and William Widger and Harold L Kohn},
  journal={The Journal of organic chemistry},
  year={2001},
  volume={66 7},
  pages={
          2251-64
        }
}
Bicyclomycin (1) is a novel antibiotic that targets rho transcription termination factor in Escherichia coli. We have demonstrated that retention of the C(5)-C(5a) exomethylene unit in 1 is not essential for inhibition. In a recent paper we proposed a working model for 1 and rho function and suggested that 1 binds in a cleft with the C(5)-C(5a) exomethylene unit directed toward the dimeric interface of two rho monomers. This report examines the bicyclomycin C(5)-C(5a) structural constraints… 
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