C‐terminus of a hexapeptidic ghrelin receptor inverse agonist can switch peptide behavior from inverse agonism to agonism

@article{ElsHeindl2016CterminusOA,
  title={C‐terminus of a hexapeptidic ghrelin receptor inverse agonist can switch peptide behavior from inverse agonism to agonism},
  author={Sylvia Els-Heindl and K. Bellmann-Sickert and A. Beck-Sickinger},
  journal={Peptide Science},
  year={2016},
  volume={106}
}
Subtle changes in the sequence at the N‐terminus and in the aromatic core of hexapeptidic ghrelin receptor inverse agonists can switch behavior from inverse agonism to agonism, but the C‐terminal role of the sequence is unclear. Thus, analogs of the ghrelin receptor inverse agonist KbFwLL‐NH2 (b = β‐(3‐benzothienyl)‐d‐alanine) were synthesized by solid phase peptide synthesis in order to identify the influence of aromaticity, charge, and hydrophobicity. Potency and efficacy of the hexapeptides… Expand
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