C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival.

@article{Buck2001CEBPbetaPB,
  title={C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival.},
  author={Martina Buck and Valeria Poli and Tony Hunter and Mario Chojkier},
  journal={Molecular cell},
  year={2001},
  volume={8 4},
  pages={807-16}
}
Upon activation by liver injury, hepatic stellate cells produce excessive fibrous tissue leading to cirrhosis. The hepatotoxin CCl(4) induced activation of RSK, phosphorylation of C/EBPbeta on Thr(217), and proliferation of stellate cells in normal mice, but caused apoptosis of these cells in C/EBPbeta-/- or C/EBPbeta-Ala(217) (a dominant-negative nonphosphorylatable mutant) transgenic mice. Both C/EBPbeta-PThr(217) and the phosphorylation mimic C/EBPbeta-Glu(217), but not C/EBPbeta-Ala(217… CONTINUE READING

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