C/EBPalpha is required for lung maturation at birth.

  title={C/EBPalpha is required for lung maturation at birth.},
  author={Prithy C Martis and Jeffrey A. Whitsett and Yan Xu and Anne Karina Perl and Huajing Wan and Machiko Ikegami},
  volume={133 6},
Epithelial cells lining the peripheral lung synthesize pulmonary surfactant that reduces surface tension at the air-liquid interface. Lack of surfactant lipids and proteins in the lungs causes respiratory distress syndrome, a common cause of morbidity and mortality in preterm infants. We show that C/EBPalpha plays a crucial role in the maturation of the respiratory epithelium in late gestation, being required for the production of surfactant lipids and proteins necessary for lung function… CONTINUE READING


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