C/EBPalpha determines hematopoietic cell fate in multipotential progenitor cells by inhibiting erythroid differentiation and inducing myeloid differentiation.

@article{Suh2006CEBPalphaDH,
  title={C/EBPalpha determines hematopoietic cell fate in multipotential progenitor cells by inhibiting erythroid differentiation and inducing myeloid differentiation.},
  author={Hyung Chan Suh and John M. Gooya and Katie Renn and Alan D Friedman and Peter Frederick Johnson and Jonathan R. Keller},
  journal={Blood},
  year={2006},
  volume={107 11},
  pages={4308-16}
}
C/EBPalpha is an essential transcription factor required for myeloid differentiation. While C/EBPalpha can act as a cell fate switch to promote granulocyte differentiation in bipotential granulocyte-macrophage progenitors (GMPs), its role in regulating cell fate decisions in more primitive progenitors is not known. We found increased numbers of erythroid progenitors and erythroid cells in C/EBPalpha(-/-) fetal liver (FL). Also, enforced expression of C/EBPalpha in hematopoietic stem cells… CONTINUE READING
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