C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo.

@article{Heath2004CEBPalphaDR,
  title={C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo.},
  author={Victoria Heath and Hyung Chan Suh and Matthew E Holman and Katie Renn and John M. Gooya and Sarah Parkin and Kimberly D. Klarmann and Mariaestela Ortiz and Peter E. Johnson and Jonathan Keller},
  journal={Blood},
  year={2004},
  volume={104 6},
  pages={1639-47}
}
CCAAT enhancer binding protein-alpha (C/EBPalpha) inhibits proliferation in multiple cell types; therefore, we evaluated whether C/EBPalpha-deficient hematopoietic progenitor cells (HPCs) have an increased proliferative potential in vitro and in vivo. In this study we demonstrate that C/EBPalpha(-/-) fetal liver (FL) progenitors are hyperproliferative, show decreased differentiation potential, and show increased self-renewal capacity in response to hematopoietic growth factors (HGFs). There are… CONTINUE READING

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