• Medicine
  • Published in
    Current opinion in genetics…
    1995

C/EBP alpha: a critical regulator of genes governing integrative metabolic processes.

@article{Darlington1995CEBPAA,
  title={C/EBP alpha: a critical regulator of genes governing integrative metabolic processes.},
  author={Gretchen J. Darlington and Nai-dy Wang and Richard W. Hanson},
  journal={Current opinion in genetics & development},
  year={1995},
  volume={5 5},
  pages={
          565-70
        }
}
The role of C/EBPalpha in the developmental expression of a subset of genes governing essential metabolic processes has recently been elucidated using a mutant mouse model that lacks this transcription factor. The mutation results in a failure of the liver and white and brown adipose tissue to develop normal metabolic functions in the immediate perinatal period, including hepatic glycogen synthesis and gluconeogenesis and the synthesis and deposition of triglyceride in adipose tissue. The… CONTINUE READING

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