C/EBP-β-activated microRNA-223 promotes tumour growth through targeting RASA1 in human colorectal cancer

@inproceedings{Sun2015CEBPactivatedMP,
  title={C/EBP-β-activated microRNA-223 promotes tumour growth through targeting RASA1 in human colorectal cancer},
  author={Defang Sun and Chengfeng Wang and Shuo Long and Yu-Qiang Ma and Yang Guo and Zan Huang and Xian Hui Chen and Changsheng Zhang and Justin P. Chen and Junyi Zhang},
  booktitle={British Journal of Cancer},
  year={2015}
}
Background:Evidences have shown that the RAS signalling pathway plays an important role in colorectal cancer (CRC). Moreover, RAS-GTPase-activating proteins (RASGAPs) as RAS signalling terminators are associated with tumourigenicity and tumour progression. In this study, we used bioinformatics analysis to predict and study important miRNAs that could target RAS p21 GTPase-activating protein 1 (RASA1), an important member of RASGAPs.Methods:The levels of RASA1 and miR-223 were analysed by real… CONTINUE READING

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