C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia.

@article{AlberichJord2012CEBPDR,
  title={C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia.},
  author={Meritxell Alberich-Jord{\`a} and Bas J. Wouters and Martin Balastik and Clara Shapiro-Koss and Hong Zhang and Annalisa Di Ruscio and Hanna S. Radomska and Alexander K. Ebralidze and Giovanni Amabile and Min Ye and Junyan Zhang and Irene Lowers and Roberto Avellino and Ari Melnick and Maria Eugenia Figueroa and Peter J. M. Valk and Ruud Delwel and Daniel G Tenen},
  journal={The Journal of clinical investigation},
  year={2012},
  volume={122 12},
  pages={4490-504}
}
C/EBPs are a family of transcription factors that regulate growth control and differentiation of various tissues. We found that C/EBPγ is highly upregulated in a subset of acute myeloid leukemia (AML) samples characterized by C/EBPα hypermethylation/silencing. Similarly, C/EBPγ was upregulated in murine hematopoietic stem/progenitor cells lacking C/EBPα, as… CONTINUE READING