C/EBPβ couples dopamine signalling to substance P precursor gene expression in striatal neurones

@article{Kovcs2006CEBPCD,
  title={C/EBP$\beta$ couples dopamine signalling to substance P precursor gene expression in striatal neurones},
  author={K. Kov{\'a}cs and M. Steinmann and P. Magistretti and O. Halfon and J. Cardinaux},
  journal={Journal of Neurochemistry},
  year={2006},
  volume={98}
}
Dopamine‐induced changes in striatal gene expression are thought to play an important role in drug addiction and compulsive behaviour. In this study we report that dopamine induces the expression of the transcription factor CCAAT/Enhancer Binding Protein β (C/EBP)‐β in primary cultures of striatal neurones. We identifed the preprotachykinin‐A (PPT‐A) gene coding for substance P and neurokinin‐A as a potential target gene of C/EBPβ. We demonstrated that C/EBPβ physically interacts with an… Expand
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