C/EBPβ Controls Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling

@article{Bostrm2010CEBPCE,
  title={C/EBPβ Controls Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling},
  author={Pontus Bostr{\"o}m and Nina Mann and Jun Wu and Pablo A. Quintero and Eva R. Plovie and Daniela Pan{\'a}kov{\'a} and Rana K Gupta and Chunyang Xiao and Calum A. MacRae and Anthony Rosenzweig and Bruce M. Spiegelman},
  journal={Cell},
  year={2010},
  volume={143},
  pages={1072-1083}
}
The heart has the ability to grow in size in response to exercise, but little is known about the transcriptional mechanisms underlying physiological hypertrophy. Adult cardiomyocytes have also recently been proven to hold the potential for proliferation, a process that could be of great importance for regenerative medicine. Using a unique RT-PCR-based screen against all transcriptional components, we showed that C/EBPβ was downregulated with exercise, whereas the expression of CITED4 was… CONTINUE READING
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