C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells

@article{Stefano2014CEBPPB,
  title={C/EBP$\alpha$ poises B cells for rapid reprogramming into induced pluripotent stem cells},
  author={Bruno Di Stefano and Jos{\'e} Luis Sardina and Chris van Oevelen and Samuel Collombet and Eric M. Kallin and Guillermo P Vicent and Jun Lu and Denis Thieffry and Miguel Beato and Thomas Graf},
  journal={Nature},
  year={2014},
  volume={506},
  pages={235-239}
}
CCAAT/enhancer binding protein-α (C/EBPα) induces transdifferentiation of B cells into macrophages at high efficiencies and enhances reprogramming into induced pluripotent stem (iPS) cells when co-expressed with the transcription factors Oct4 (Pou5f1), Sox2, Klf4 and Myc (hereafter called OSKM). However, how C/EBPα accomplishes these effects is unclear. Here we find that in mouse primary B cells transient C/EBPα expression followed by OSKM activation induces a 100-fold increase in iPS cell… 

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