C/EBPα knock-in hepatocytes exhibit increased albumin secretion and urea production

The CCAAT/enhancer-binding protein α (C/EBPα) is essential for maintaining the differentiated state of hepatocytes in vivo. C/EBPα activates albumin transcription and coordinates the expression of multiple ornithine cycle enzymes involved in urea production. We have examined the effects of the C/EBPα knock-in gene on the mRNA and protein expression of genes… (More)