C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter.

@article{Oelgeschlger1996CEBPCA,
  title={C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter.},
  author={Michael Oelgeschl{\"a}ger and Issarang Nuchprayoon and Bernhard L{\"u}scher and Alan D Friedman},
  journal={Molecular and cellular biology},
  year={1996},
  volume={16 9},
  pages={4717-25}
}
The murine neutrophil elastase (NE) gene is expressed specifically in immature myeloid cells. A 91-bp NE promoter region contains three cis elements which are conserved evolutionarily and are essential for activation of the promoter in differentiating 32D cl3 myeloid cells. These elements bound c-Myb (at -49), C/EBPalpha (at -57), and PU.1 (at -82). In NIH 3T3 cells, the NE promoter was activated by c-Myb, C/EBPalpha, and PU.1, via their respective binding sites. Cooperative activation was seen… CONTINUE READING