C(60) and water-soluble fullerene derivatives as antioxidants against radical-initiated lipid peroxidation.

  title={C(60) and water-soluble fullerene derivatives as antioxidants against radical-initiated lipid peroxidation.},
  author={I C Wang and Lin Ai Tai and Daniel D Lee and P P Kanakamma and Clifton K.-F. Shen and T Y Luh and Chien Hong Cheng and Ki Chul Hwang},
  journal={Journal of medicinal chemistry},
  volume={42 22},
C(60), vitamin E, and three C(60) derivatives (polar 1 and water-soluble C(3)/D(3)C(60)s) were examined for their antioxidant effects on prevention of lipid peroxidation induced by superoxide and hydroxyl radicals. The protection effect on lipid peroxidation was found to be in the sequence: C(60) >/= vitamin E > 1 > none, for liposoluble antioxidants, and C(3)C(60) >> D(3)C(60) > none, for water-soluble ones. Fluorescence quenching of PyCH(2)COOH (Py = pyrene) by both C(3)- and D(3)C(60)s shows… CONTINUE READING

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