Bystander or no bystander for gene directed enzyme prodrug therapy.

  title={Bystander or no bystander for gene directed enzyme prodrug therapy.},
  author={Gabi Ursula Dachs and Michelle A Hunt and Sophie P Syddall and Dean C. Singleton and Adam Vorn Patterson},
  volume={14 11},
Gene directed enzyme prodrug therapy (GDEPT) of cancer aims to improve the selectivity of chemotherapy by gene transfer, thus enabling target cells to convert nontoxic prodrugs to cytotoxic drugs. A zone of cell kill around gene-modified cells due to transfer of toxic metabolites, known as the bystander effect, leads to tumour regression. Here we discuss the implications of either striving for a strong bystander effect to overcome poor gene transfer, or avoiding the bystander effect to reduce… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
37 Extracted Citations
174 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 37 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 174 references

Similar Papers

Loading similar papers…