Bystander or no bystander for gene directed enzyme prodrug therapy.

@article{Dachs2009BystanderON,
  title={Bystander or no bystander for gene directed enzyme prodrug therapy.},
  author={Gabi Ursula Dachs and Michelle A Hunt and Sophie P Syddall and Dean C. Singleton and Adam Vorn Patterson},
  journal={Molecules},
  year={2009},
  volume={14 11},
  pages={4517-45}
}
Gene directed enzyme prodrug therapy (GDEPT) of cancer aims to improve the selectivity of chemotherapy by gene transfer, thus enabling target cells to convert nontoxic prodrugs to cytotoxic drugs. A zone of cell kill around gene-modified cells due to transfer of toxic metabolites, known as the bystander effect, leads to tumour regression. Here we discuss the implications of either striving for a strong bystander effect to overcome poor gene transfer, or avoiding the bystander effect to reduce… CONTINUE READING

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