Bystander activation of CD8+ T lymphocytes during experimental mycobacterial infection.

@article{Gilbertson2004BystanderAO,
  title={Bystander activation of CD8+ T lymphocytes during experimental mycobacterial infection.},
  author={Brad P Gilbertson and Susie Germano and Pauline M Steele and Steven Turner and Barbara Fazekas de St Groth and Christina Cheers},
  journal={Infection and immunity},
  year={2004},
  volume={72 12},
  pages={6884-91}
}
Infection of C57BL/6 mice with Mycobacterium avium leads to the activation of both CD4+ and CD8+ gamma interferon (IFN-gamma)-producing T cells, although the CD8+ cells play no role in protection against infection. Using transfer of different lines of transgenic T cells with T-cell receptors (TCRs) which recognize irrelevant antigens, we show here that transferred CD8+ T cells from two of the three lines were activated to the same degree as the host cells, suggesting that the majority of the… CONTINUE READING

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