Bystander activation of CD4(+) T cells can represent an exclusive means of immunopathology in a virus infection.

@article{Gangappa1999BystanderAO,
  title={Bystander activation of CD4(+) T cells can represent an exclusive means of immunopathology in a virus infection.},
  author={Sreeramaiah N. Gangappa and Shilpa P Deshpande and Barry T Rouse},
  journal={European journal of immunology},
  year={1999},
  volume={29 11},
  pages={3674-82}
}
Herpetic stromal keratitis (HSK) is an immunopathological lesion involving herpes simplex virus (HSV) infection and CD4(+) T cells of the Th1 phenotype, but the nature of the target antigens which drive HSK remains uncertain. In the present report we show that ovalbumin TCR-transgenic mice backcrossed to SCID mice unable to recognize HSV show clinical signs of HSK but die of viral encephalitis before the lesions become severe. However, passive transfer of anti-HSV serum at 24 h clears virus and… CONTINUE READING

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