Bypassing the midgut results in development of Plasmodium berghei oocysts in a refractory strain of Anopheles gambiae (Diptera: Culicidae).

@article{Paskewitz2005BypassingTM,
  title={Bypassing the midgut results in development of Plasmodium berghei oocysts in a refractory strain of Anopheles gambiae (Diptera: Culicidae).},
  author={Susan M. Paskewitz and Lei Shi},
  journal={Journal of medical entomology},
  year={2005},
  volume={42 4},
  pages={712-5}
}
The L35 strain of Anopheles gambiae Giles was genetically selected for its ability to melanize and kill malaria parasites. A wide range of Plasmodium species are subject to this response when orally ingested, including the rodent malaria, P. berghei. However, when we directly injected P. berghei into the hemocoel, we found that parasites developed normally to the oocyst stage. This work suggests that the parasite melanization response depends on the interaction of the ookinetes and the midgut… CONTINUE READING