Bypassing melanocyte senescence by beta-catenin: a novel way to promote melanoma.

@article{Larue2009BypassingMS,
  title={Bypassing melanocyte senescence by beta-catenin: a novel way to promote melanoma.},
  author={Lionel Larue and Flavie Luciani and Mayuko Y. Kumasaka and Delphine Champeval and Neşe Demirkan and Jacky Bonaventure and V{\'e}ronique Delmas},
  journal={Pathologie-biologie},
  year={2009},
  volume={57 7-8},
  pages={
          543-7
        }
}
The Wnt/beta-catenin signaling pathway plays a key role in several cellular functions during embryonic development and adult homeostasis. The deregulation of this pathway may lead to the development of cancer, including melanoma. Deregulation of the Wnt/beta-catenin pathway occurs through either the induction/repression of, or specific mutations in, various members of this signaling pathway; this results in the stabilization of beta-catenin and its translocation from the cytoplasm to the… CONTINUE READING

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