Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus.

@article{Dietrich2007BypassOS,
  title={Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus.},
  author={N. Dietrich and Adrian P Bracken and Emmanuelle Trinh and Charlotte Karlskov Schjerling and Haruhiko Koseki and Juri Rappsilber and Kristian Helin and Klaus H. Hansen},
  journal={The EMBO journal},
  year={2007},
  volume={26 6},
  pages={1637-48}
}
The Polycomb group (PcG) proteins are essential for embryogenesis, and their expression is often found deregulated in human cancer. The PcGs form two major protein complexes, called polycomb repressive complexes 1 and 2 (PRC1 and PRC2) whose function is to maintain transcriptional repression. Here, we demonstrate that the chromodomain-containing protein, CBX8, which is part of one of the PRC1 complexes, regulates proliferation of diploid human and mouse fibroblasts through direct binding to the… CONTINUE READING

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