Bypass mechanisms of resistance to receptor tyrosine kinase inhibition in lung cancer.

@article{Niederst2013BypassMO,
  title={Bypass mechanisms of resistance to receptor tyrosine kinase inhibition in lung cancer.},
  author={Matthew J. Niederst and Jeffrey A. Engelman},
  journal={Science signaling},
  year={2013},
  volume={6 294},
  pages={re6}
}
Receptor tyrosine kinases (RTKs) are activated by somatic genetic alterations in a subset of cancers, and such cancers are often sensitive to specific inhibitors of the activated kinase. Two well-established examples of this paradigm include lung cancers with either EGFR mutations or ALK translocations. In these cancers, inhibition of the corresponding RTK leads to suppression of key downstream signaling pathways, such as the PI3K (phosphatidylinositol 3-kinase)/AKT and MEK (mitogen-activated… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 19 times over the past 90 days. VIEW TWEETS
84 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 84 extracted citations

Similar Papers

Loading similar papers…