Butyrylcholinesterase K variant associated with higher enzyme activity in the temporal cortex of elderly patients.


There is evidence to suggest an involvement of the K variant of the butyrylcholinesterase gene (BCHE) in dementia. We have examined the relationship between BCHE genotype and butyrylcholinesterase (BuChE) activity in autopsy brain tissue. We studied 164 autopsy cases, 144 with dementia and 20 controls, including 13 K homozygotes and 48 K heterozygotes, from… (More)
DOI: 10.1016/j.neulet.2008.07.023


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