Butyrophilin Btn2a2 Inhibits TCR Activation and Phosphatidylinositol 3-Kinase/Akt Pathway Signaling and Induces Foxp3 Expression in T Lymphocytes

@article{Ammann2013ButyrophilinBI,
  title={Butyrophilin Btn2a2 Inhibits TCR Activation and Phosphatidylinositol 3-Kinase/Akt Pathway Signaling and Induces Foxp3 Expression in T Lymphocytes},
  author={Johannes U. Ammann and Anne Cooke and John Trowsdale},
  journal={The Journal of Immunology},
  year={2013},
  volume={190},
  pages={5030 - 5036}
}
The butyrophilin-related protein Btn2a2 was upregulated on murine APC including CD19+ B cells, CD11b+F4/80+ peritoneal macrophages, and CD11c+ bone marrow–derived dendritic cells after activation with LPS or Pam3CysK4, suggesting a role in modulation of T lymphocytes. Consistent with this, binding of mouse Btn2a2-Fc to CD3+ primary mouse T cells stimulated with anti-CD3 and anti-CD28 reduced the number of proliferating cells and entry of cells into the cell cycle. Binding of Btn2a2-Fc to anti… 

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