Butyrate switches the pattern of chemokine secretion by intestinal epithelial cells through histone acetylation.

@article{Fusunyan1999ButyrateST,
  title={Butyrate switches the pattern of chemokine secretion by intestinal epithelial cells through histone acetylation.},
  author={Robert D Fusunyan and Jessica J Quinn and Mitsuaki Fujimoto and Richard P Macdermott and Ian R Sanderson},
  journal={Molecular medicine},
  year={1999},
  volume={5 9},
  pages={
          631-40
        }
}
BACKGROUND Butyrate, a fermentation product of intestinal bacteria, modifies chromatin structure through histone acetylation, thereby altering gene transcription. IL-8 and MCP-1 are chemokines, expressed by intestinal epithelial cells, which attract neutrophils and monocytes, respectively. We hypothesized that butyrate may alter IL-8 and MCP-1 expression by intestinal epithelial cells through histone acetylation. MATERIALS AND METHODS IL-8 and MCP-1 expression was measured by ELISA and RNA… CONTINUE READING