Butyrate suppresses mRNA increase of osteopontin and cyclooxygenase-2 in human colon tumor tissue.

@article{Jahns2011ButyrateSM,
  title={Butyrate suppresses mRNA increase of osteopontin and cyclooxygenase-2 in human colon tumor tissue.},
  author={Franziska Jahns and Anne Marie Wilhelm and Nadja Jablonowski and Henning Mothes and Mariya Yosifova Radeva and Anja W{\"o}lfert and Karl Otto Greulich and Michael Glei},
  journal={Carcinogenesis},
  year={2011},
  volume={32 6},
  pages={913-20}
}
The short chain fatty acid (SCFA) butyrate, a product of fermentation of dietary fiber in the human colon, is found to exert multiple regulatory processes in colon carcinogenesis. The aim of this study was to find out whether butyrate affects the tumor-promoting genes osteopontin (OPN) and cyclooxygenase (COX)-2, their respective proteins and/or their functional activity in matched normal, adenoma and tumor colon tissues obtained from 20 individuals at colon cancer surgery. Quantitative real… CONTINUE READING