Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells.

@article{Zimmerman2012ButyrateSC,
  title={Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells.},
  author={Mary A. Zimmerman and Nagendra Singh and Pamela Moore Martin and Muthusamy Thangaraju and Vadivel Ganapathy and Jennifer L Waller and Huidong Shi and Keith D. Robertson and David H. Munn and Kebin Liu},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2012},
  volume={302 12},
  pages={G1405-15}
}
Butyrate, an intestinal microbiota metabolite of dietary fiber, has been shown to exhibit protective effects toward inflammatory diseases such as ulcerative colitis (UC) and inflammation-mediated colorectal cancer. Recent studies have shown that chronic IFN-γ signaling plays an essential role in inflammation-mediated colorectal cancer development in vivo, whereas genome-wide association studies have linked human UC risk loci to IFNG, the gene that encodes IFN-γ. However, the molecular… CONTINUE READING