Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose.

@article{Gaudier2004ButyrateSM,
  title={Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose.},
  author={Estelle A. Gaudier and Anne Jarry and Herv{\'e} M Blotti{\`e}re and Pierre de Coppet and Marie-Pierre Buisine and J. P. Aubert and Christian L. Laboisse and Christine Cherbut and Christine Hoebler},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2004},
  volume={287 6},
  pages={
          G1168-74
        }
}
The mucus layer covering the gastrointestinal mucosa is considered the first line of defense against aggressions arising from the luminal content. It is mainly composed of high molecular weight glycoproteins called mucins. Butyrate, a short-chain fatty acid produced during carbohydrate fermentation, has been shown to increase mucin secretion. The aim of this study was to test 1) whether butyrate regulates the expression of various MUC genes, which are coding for protein backbones of mucins, and… CONTINUE READING

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