Butyrate sensitizes human colon cancer cells to TRAIL-mediated apoptosis.

@article{Hernndez2001ButyrateSH,
  title={Butyrate sensitizes human colon cancer cells to TRAIL-mediated apoptosis.},
  author={Ariadna Hern{\'a}ndez and Regi Thomas and Fiona Smith and J A Sandberg and Sunghoon Kim and Dai H. Chung and Bernard Mark Evers},
  journal={Surgery},
  year={2001},
  volume={130 2},
  pages={265-72}
}
BACKGROUND Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a novel member of the tumor necrosis factor family, induces apoptosis in TRAIL-sensitive tumors through the activation of the caspase pathway. Sodium butyrate (NaBT) induces differentiation and apoptosis in certain colorectal cancers; the molecular mechanisms for these effects have not been clearly defined. The purpose of our study was to determine whether NaBT sensitizes TRAIL-resistant human colon cancer cells to the… CONTINUE READING