Butyrate regulation of glycosylation-related gene expression: evidence for galectin-1 upregulation in human intestinal epithelial goblet cells.

@article{Gaudier2004ButyrateRO,
  title={Butyrate regulation of glycosylation-related gene expression: evidence for galectin-1 upregulation in human intestinal epithelial goblet cells.},
  author={Estelle A. Gaudier and Lionel Forestier and Val{\'e}rie Gouyer and G. Huet and Raymond Julien and Christine Hoebler},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={325 3},
  pages={
          1044-51
        }
}
Glycosylation of mucins produced by human intestinal goblet cells plays a crucial role in their functions: mucus gel physico-chemical protective properties, host-bacteria interactions, cell-cell adhesion, cell migration, and cell signaling. Colonic mucin glycosylation can be modified by luminal metabolites of fiber fermentation like butyrate. Our aim was to assess the effect of butyrate on the expression of a large panel of glycosylation-related genes in human intestinal epithelial goblet cells… CONTINUE READING
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