Butyrate promotes induced pluripotent stem cell generation.

  title={Butyrate promotes induced pluripotent stem cell generation.},
  author={Gaoyang Liang and Olena Taranova and Kai Xia and Yi Irvette Zhang},
  journal={The Journal of biological chemistry},
  volume={285 33},
Recent studies have demonstrated that embryonic stem cell-like induced pluripotent stem (iPS) cells can be generated by enforced expression of defined transcription factors. The fact that cell fate change is accompanied by changes in epigenetic modifications prompted us to investigate whether chemicals known to modulate epigenetic regulators are capable of enhancing the efficiency of iPS cell generation. Here, we report that butyrate, a natural small fatty acid and histone deacetylase inhibitor… CONTINUE READING
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Stem Cells

  • P. Mali, B. K. Chou, +13 authors L. Cheng
  • AUGUST 13,
  • 2010

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