Butyrate modulates intestinal epithelial cell-mediated neutrophil migration.

  title={Butyrate modulates intestinal epithelial cell-mediated neutrophil migration.},
  author={Ulrich B{\"o}cker and Thomas C. Nebe and Frank Herweck and Lisa Holt and Asit Panja and Christian Jobin and Siegbert Rossol and R B Sartor and Manfred Vincenz Singer},
  journal={Clinical and experimental immunology},
  volume={131 1},
Butyrate, a short-chain fatty acid released by colonic bacteria and administered therapeutically in inflammatory bowel diseases, exerts immunomodulatory properties. The aim of the study was to determine the functional consequences of butyrate exposure on the proinflammatory responsiveness of human intestinal epithelial cells (IEC). IL-8 promoter activity in IEC pretreated with butyrate then exposed to proinflammatory stimuli was assayed by transfection of luciferase constructs. IL-8 secretion… CONTINUE READING