Butyrate modulates gene and protein expression in human intestinal endothelial cells.

@article{Ogawa2003ButyrateMG,
  title={Butyrate modulates gene and protein expression in human intestinal endothelial cells.},
  author={Hitoshi Ogawa and Parvaneh Rafiee and Pamela J. Fisher and Nathan A. Johnson and Mary Francis Otterson and David G. Binion},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={309 3},
  pages={512-9}
}
We hypothesized that sodium butyrate, a product of enteric bacterial fermentation, modulates gene expression in gut microvascular endothelium which plays a central role in mucosal immunity. We examined sodium butyrate's effect on LPS-induced gene and protein expression in primary cultures of human intestinal microvascular endothelial cells. cDNA array analysis revealed that sodium butyrate augmented ICAM-1 mRNA expression, while it inhibited IL-6 and COX-2 expression in response to LPS… CONTINUE READING

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