Butyrate metabolism upstream and downstream acetyl-CoA synthesis and growth control of human colon carcinoma cells.

@article{Leschelle2000ButyrateMU,
  title={Butyrate metabolism upstream and downstream acetyl-CoA synthesis and growth control of human colon carcinoma cells.},
  author={Xavier Leschelle and Serge Delpal and Marc Goubern and Herv{\'e} M Blotti{\`e}re and François Blachier},
  journal={European journal of biochemistry},
  year={2000},
  volume={267 21},
  pages={6435-42}
}
Butyrate is a short chain fatty acid (SCFA) produced by bacterial fermentation of dietary fibers in the colon lumen which severely affects the proliferation of colon cancer cells in in vitro experiments. Although butyrate is able to interfere with numerous cellular targets including cell cycle regulator expression, little is known about butyrate metabolism and its possible involvement in its effect upon colon carcinoma cell growth. In this study, we found that HT-29 Glc-/+ cells strongly… CONTINUE READING
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