Butyrate induces glutathione S-transferase in human colon cells and protects from genetic damage by 4-hydroxy-2-nonenal.

@article{Ebert2001ButyrateIG,
  title={Butyrate induces glutathione S-transferase in human colon cells and protects from genetic damage by 4-hydroxy-2-nonenal.},
  author={Miriam Nannette Ebert and Gabriele Beyer-Sehlmeyer and Ute Monika Liegibel and Tanja Kautenburger and Thomas W. Becker and Beatrice Louise Pool-Zobel},
  journal={Nutrition and cancer},
  year={2001},
  volume={41 1-2},
  pages={156-64}
}
Butyrate, one of the major products of gut fermentation, is known to inhibit proliferation, induce apoptosis and differentiation, and increase phase II enzyme activities in tumor cells, whereas little information is available on protective effects in less-transformed colon cells. The aim of this study was to investigate whether the chemoprotective mechanism of glutathione S-transferase (GST) induction by butyrate could also play a role in earlier stages of colon carcinogenesis and whether… CONTINUE READING

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