Butyrate-enhanced TNFalpha-induced apoptosis is associated with inhibition of NF-kappaB.

@article{Luehrs2002ButyrateenhancedTA,
  title={Butyrate-enhanced TNFalpha-induced apoptosis is associated with inhibition of NF-kappaB.},
  author={Hardi Luehrs and Theodor Kudlich and Manfred Dr. Neumann and Juergen Schauber and Ralph Melcher and Andrea Gostner and Wolfgang M Scheppach and Thomas P. Menzel},
  journal={Anticancer research},
  year={2002},
  volume={22 3},
  pages={
          1561-8
        }
}
BACKGROUND Tumor necrosis factor (TNFalpha)-induced apoptosis is limited by concomitant activation of nuclear factor kappa B (NF-kappaB)-dependent anti-apoptotic genes. Butyrate inhibits NF-kappaB activation so that co-treatment with butyrate effectively enhances TNFalpha-induced apoptosis. In this context, the inhibition of NF-kappaB activation and subsequent modulation of (NF-kappaB)-dependent genes was assessed MATERIALS AND METHODS Human colon adenocarcinoma cells (SW620) were incubated… CONTINUE READING

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