Butyrate enemas upregulate Muc genes expression but decrease adherent mucus thickness in mice colon.

@article{Gaudier2009ButyrateEU,
  title={Butyrate enemas upregulate Muc genes expression but decrease adherent mucus thickness in mice colon.},
  author={Estelle Gaudier and Martine Rival and M-P Buisine and Isabelle Robineau and Christine Hoebler},
  journal={Physiological research},
  year={2009},
  volume={58 1},
  pages={
          111-9
        }
}
Colonic mucosal protection is provided by the mucus gel, mainly composed of mucins. Several factors can modulate the formation and the secretion of mucins, and among them butyrate, an end-product of carbohydrate fermentation. However, the specific effect of butyrate on the various colonic mucins, and the consequences in terms of the mucus layer thickness are not known. Our aim was to determine whether butyrate modulates colonic MUC genes expression in vivo and whether this results in changes in… CONTINUE READING

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