Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex

@article{Blouin2011ButyrateEA,
  title={Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex},
  author={Jean-Marc Blouin and Graziella Penot and Martine Collinet and Magali Nacfer and Claude Forest and Pierre Laurent-Puig and Xavier Coumoul and Robert Barouki and Chantal Benelli and Sylvie Bortoli},
  journal={International Journal of Cancer},
  year={2011},
  volume={128}
}
Butyrate, a short‐chain fatty acid produced by the colonic bacterial fermentation is able to induce cell growth inhibition and differentiation in colon cancer cells at least partially through its capacity to inhibit histone deacetylases. Since butyrate is expected to impact cellular metabolic pathways in colon cancer cells, we hypothesize that it could exert its antiproliferative properties by altering cellular metabolism. We show that although Caco2 colon cancer cells oxidized both butyrate… 

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