Butyrate delivered by butyrylated starch increases distal colonic epithelial apoptosis in carcinogen-treated rats

@inproceedings{Clarke2012ButyrateDB,
  title={Butyrate delivered by butyrylated starch increases distal colonic epithelial apoptosis in carcinogen-treated rats},
  author={JohnM. Clarke and Graeme P. Young and DavidL. Topping and Anthony Richard Bird and Lynne Cobiac and Benjamin L. Scherer and Jessica G. Winkler and Trevor J. Lockett},
  booktitle={Carcinogenesis},
  year={2012}
}
Animal studies show that increasing large bowel butyrate concentration through ingestion of butyrylated or resistant starches opposes carcinogen-induced tumorigenesis, which is consistent with population data linking greater fiber consumption with lowered colorectal cancer (CRC) risk. Butyrate has been shown to regulate the apoptotic response to DNA damage. This study examined the impact of increasing large bowel butyrate concentration by dietary butyrylated starch on the colonic epithelium of… CONTINUE READING
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