Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

@article{Gao2009ButyrateII,
  title={Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice},
  author={Zhanguo Gao and Jun-yi Yin and Jin Zhang and Robert E. Ward and Roy J Martin and Michael Lefevre and William T. Cefalu and Jianping Ye},
  journal={Diabetes},
  year={2009},
  volume={58},
  pages={1509 - 1517}
}
OBJECTIVE We examined the role of butyric acid, a short-chain fatty acid formed by fermentation in the large intestine, in the regulation of insulin sensitivity in mice fed a high-fat diet. RESEARCH DESIGN AND METHODS In dietary-obese C57BL/6J mice, sodium butyrate was administrated through diet supplementation at 5% wt/wt in the high-fat diet. Insulin sensitivity was examined with insulin tolerance testing and homeostasis model assessment for insulin resistance. Energy metabolism was monitored… Expand
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