Butyrate, an HDAC inhibitor, stimulates interplay between different posttranslational modifications of histone H3 and differently alters G1-specific cell cycle proteins in vascular smooth muscle cells.

@article{Mathew2010ButyrateAH,
  title={Butyrate, an HDAC inhibitor, stimulates interplay between different posttranslational modifications of histone H3 and differently alters G1-specific cell cycle proteins in vascular smooth muscle cells.},
  author={Omana P. Mathew and Kasturi Ranganna and Frank M. Yatsu},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2010},
  volume={64 10},
  pages={733-40}
}
HDACs and HATs regulate histone acetylation, an epigenetic modification that controls chromatin structure and through it, gene expression. Butyrate, a dietary HDAC inhibitor, inhibits VSMC proliferation, a crucial factor in atherogenesis, and the principle mechanism in arterial and in-stent restenosis. Here, the link between antiproliferation action of butyrate and the portraits of global covalent modifications of histone H3 that it induces are characterized to understand the mechanics of… CONTINUE READING

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