• Corpus ID: 7989979

Butterbur Ze 339 for the Treatment of Intermittent Allergic Rhinitis Dose-Dependent Efficacy in a Prospective , Randomized , Double-blind , Placebo-Controlled Study

@inproceedings{SchapowalButterburZ3,
  title={Butterbur Ze 339 for the Treatment of Intermittent Allergic Rhinitis Dose-Dependent Efficacy in a Prospective , Randomized , Double-blind , Placebo-Controlled Study},
  author={Andreas Schapowal}
}
Results: Improvement in the main efficacy variable was significantly superior in the Butterbur Ze339 groups, relative to placebo, and a significant dose relationship was observed between the 2 Butterbur doses. The clinicians’ assessment of efficacy and the overall responder rates were significantly superior for the active groups compared with placebo. The incidence and type of adverse events were indistinguishable across the herbal treatment and placebo groups. 
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References

SHOWING 1-10 OF 16 REFERENCES
Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis
TLDR
The effects of butterbur are similar to those of cetirizine in patients with seasonal allergic rhinitis when evaluated blindly by patients and doctors, and should be considered when the sedating effects of antihistamines must be avoided.
Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study
TLDR
Dry extract of agnus castus fruit is an effective and well tolerated treatment for the relief of symptoms of the premenstrual syndrome and indicates superiority of active treatment in each of the three global impression items.
LI 160, an extract of St. John's wort, versus amitriptyline in mildly to moderately depressed outpatients--a controlled 6-week clinical trial.
TLDR
LI 160 was clearly superior to amitriptyline, particularly in relation to anticholinergic and Central Nervous System adverse events, and could confer an advantage in improving compliance for antidepressant pharmacotherapy.
Petasins in the Treatment of Allergic Diseases: Results of Preclinical and Clinical Studies
TLDR
The clinical efficacy of the butterbur extract drug was compared with an established antihistamine treatment scheme in a double-blind study and no significant difference was observed between the two treatment groups.
Comparison of St John's wort and imipramine for treating depression: randomised controlled trial
  • H. Woelk
  • Psychology, Medicine
    BMJ : British Medical Journal
  • 2000
TLDR
This Hypericum perforatum extract is therapeutically equivalent to imipramine in treating mild to moderate depression, but patients tolerate hypericum better.
Gastro-protective effects by extracts of Petasites hybridus: the role of inhibition of peptido-leukotriene synthesis.
TLDR
It is concluded that the active principle could be useful in the treatment of gastro-intestinal human diseases and that Petasites hybridus may contribute to the inhibition of calcium-dependent processes such as leukotriene biosynthesis.
Twenty-four hour pattern in symptom intensity of viral and allergic rhinitis: Treatment implications☆☆☆★
Assessment of quality of life in patients with perennial allergic rhinitis with the French version of the SF-36 Health Status Questionnaire.
TLDR
The SF-36 Health Status Questionnaire allows discrimination between patients with perennial allergic rhinitis and healthy subjects and most QOL scores were highly reliable.
...
1
2
...