Buthionine sulfoximine increases the toxicity of nifurtimox and benznidazole to Trypanosoma cruzi.

@article{Fandez2005ButhionineSI,
  title={Buthionine sulfoximine increases the toxicity of nifurtimox and benznidazole to Trypanosoma cruzi.},
  author={Mario A Fa{\'u}ndez and Laura Pino and Paula Letelier and C. Jimenez Ortiz and Rodrigo Roca Lopez and Claudia Seguel and Jorge Viterbo Ferreira and M. Sri Pavani and Antonio Morell{\'o} and Juan D Maya},
  journal={Antimicrobial agents and chemotherapy},
  year={2005},
  volume={49 1},
  pages={126-30}
}
l-Buthionine (S,R)-sulfoximine (BSO) increased the toxicity of nifurtimox and benznidazole toward the epimastigote, trypomastigote, and amastigote forms of Trypanosoma cruzi. BSO at 500 muM decreased total glutathione-derived thiols by 70 to 80% in 48 h. In epimastigotes, 500 muM BSO decreased the concentration of nifurtimox needed to inhibit constant growth of the parasites by 50%, from 14.0 to 9.0 muM, and decreased that of benznidazole from 43.6 to 24.1 muM. The survival of epimastigotes or… CONTINUE READING